Development of a conducting polymer cell impedance sensor

Karimullah, A. S. , Cumming, D. R.S. , Riehle, M. and Gadegaard, N. (2013) Development of a conducting polymer cell impedance sensor. Sensors and Actuators B: Chemical, 176, pp. 667-674. (doi:10.1016/j.snb.2012.09.075)

Karimullah, A. S. , Cumming, D. R.S. , Riehle, M. and Gadegaard, N. (2013) Development of a conducting polymer cell impedance sensor. Sensors and Actuators B: Chemical, 176, pp. 667-674. (doi:10.1016/j.snb.2012.09.075)

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Abstract

Research in to label free methods for biological analysis have brought interesting developments. Cell impedance spectroscopy has been one of the promising outcomes. Here we show the development of an 8-well impedance measurement setup and studied the use of conducting polymers as electrode material in cell impedance spectroscopy. We have developed devices using PEDOT:PSS electrodes and shown its advantages (lower impedance and faster to reach electrochemical equilibrium) over conventional materials, such as gold. It is observed through electrochemical analysis that the lower interfacial impedance is due to the low charge transfer resistance of PEDOT:PSS. MDCK cell proliferation experiments were performed using both types of electrode materials to provide a comparative result. We applied electrical modeling methods to understand the cell–substrate interactions and shown its applications in cell impedance spectroscopy. This study presents the development and advantages of cell impedance spectroscopy using conducting polymer electrodes.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cumming, Professor David and Riehle, Dr Mathis and Karimullah, Dr Affar and Gadegaard, Professor Nikolaj
Authors: Karimullah, A. S., Cumming, D. R.S., Riehle, M., and Gadegaard, N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
College of Science and Engineering > School of Chemistry
College of Science and Engineering > School of Engineering > Biomedical Engineering
College of Science and Engineering > School of Engineering > Electronics and Nanoscale Engineering
Journal Name:Sensors and Actuators B: Chemical
Publisher:Elsevier
ISSN:0925-4005
ISSN (Online):1873-3077

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