Magneto-mechanical mixing and manipulation of picoliter volumes in vesicles

Franke, T., Schmid, L., Weitz, D. A. and Wixforth, A. (2009) Magneto-mechanical mixing and manipulation of picoliter volumes in vesicles. Lab on a Chip, 9(19), pp. 2831-2835. (doi: 10.1039/b906569p)

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Superparamagnetic beads in giant unilamellar vesicles are used to facilitate magnetic manipulation, positioning, agitation and mixing of ultrasmall liquid volumes. Vesicles act as leakproof picoliter reaction vessels in an aqueous bulk solution and can be deliberately conveyed by an external magnetic field to a designated position. Upon application of an external magnetic field the beads align to form extended chains. In a rotating magnetic field chains break up into smaller fragments caused by the interplay of viscous friction and magnetic attraction. This process obeys a simple relationship and can be exploited to enhance mixing of the vesicle content and the outer solution or adjacent vesicle volumes exactly at the position of release.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Franke, Professor Thomas and Schmid, Mr Lothar
Authors: Franke, T., Schmid, L., Weitz, D. A., and Wixforth, A.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Lab on a Chip
Publisher:Royal Society of Chemistry
ISSN (Online):1473-0189
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