From screen to target: insights and approaches for the development of anti-virulence compounds

Beckham, K. S.H. and Roe, A. J. (2014) From screen to target: insights and approaches for the development of anti-virulence compounds. Frontiers in Cellular and Infection Microbiology, 4(139), (doi: 10.3389/fcimb.2014.00139)

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Abstract

A detailed understanding of host-pathogen interactions provides exciting opportunities to interfere with the infection process. Anti-virulence compounds aim to modulate or pacify pathogenesis by reducing expression of critical virulence determinants. In particular, prevention of attachment by inhibiting adhesion mechanisms has been the subject of intense research. Whilst it has proven relatively straightforward to develop robust screens for potential anti-virulence compounds, understanding their precise mode of action has proven much more challenging. In this review we illustrate this challenge from our own experiences working with the salicylidene acylhydrazide group of compounds. We aim to provide a useful perspective to guide researchers interested in this field and to avoid some of the obvious pitfalls.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Roe, Professor Andrew
Authors: Beckham, K. S.H., and Roe, A. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Frontiers in Cellular and Infection Microbiology
Publisher:Frontiers Research Foundation
ISSN:2235-2988
ISSN (Online):2235-2988
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in Frontiers in Cellular and Infection Microbiology 4(139)
Publisher Policy:Reproduced under a Creative Commons License

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