Soni, S., Pchelintsev, N., Adams, P. D. and Bieker, J. J. (2014) Transcription factor EKLF (KLF1) recruitment of the histone chaperone HIRA is essential for -globin gene expression. Proceedings of the National Academy of Sciences of the United States of America, 111(37), pp. 13337-13342. (doi: 10.1073/pnas.1405422111)
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Abstract
The β-like globin locus has provided a long-standing model for the study of cell-specific and developmental control of transcription and chromatin structure. We have previously shown that the replication-independent histone H3.3 variant is enriched at the active adult β-globin promoter. Although the erythroid Krüppel-like factor (EKLF), which is also known as Krüppel-like factor 1 (KLF1), transcription factor interacts with histone H3, it does not distinguish between the H3.1 or H3.3 variants. We now show that EKLF interacts with the H3.3 chaperone named histone cell cycle regulation defective homolog A (HIRA) and that this enables its selective recruitment of HIRA to the promoter. To our knowledge, our studies implicate HIRA for the first time in establishment of erythropoiesis and explain how critical protein interactions can lead to directed changes in histone variants at restricted sites.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Pchelintsev, Dr Nikolay and Adams, Professor Peter |
| Authors: | Soni, S., Pchelintsev, N., Adams, P. D., and Bieker, J. J. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | Proceedings of the National Academy of Sciences of the United States of America |
| Publisher: | National Academy of Sciences |
| ISSN: | 0027-8424 |
| ISSN (Online): | 1091-6490 |
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