Oliphant, C. J. et al. (2014) MHCII-mediated dialog between group 2 innate lymphoid cells and CD4+ T cells potentiates type 2 immunity and promotes parasitic helminth expulsion. Immunity, 41(2), pp. 283-295. (doi: 10.1016/j.immuni.2014.06.016) (PMID:25088770) (PMCID:PMC4148706)
|
Text
97890.pdf - Published Version Available under License Creative Commons Attribution. 2MB |
Abstract
Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma. Using two mouse models to deplete ILC2s in vivo, we demonstrate that T helper 2 (Th2) cell responses are impaired in the absence of ILC2s. We show that MHCII-expressing ILC2s interact with antigen-specific T cells to instigate a dialog in which IL-2 production from T cells promotes ILC2 proliferation and IL-13 production. Deletion of MHCII renders IL-13-expressing ILC2s incapable of efficiently inducing Nippostrongylus brasiliensis expulsion. Thus, during transition to adaptive T cell-mediated immunity, the ILC2 and T cell crosstalk contributes to their mutual maintenance, expansion and cytokine production. This interaction appears to augment dendritic-cell-induced T cell activation and identifies a previously unappreciated pathway in the regulation of type-2 immunity.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Brewer, Professor James |
Authors: | Oliphant, C. J., Hwang, Y. Y., Walker, J. A., Salimi, M., Wong, S. H., Brewer, J. M., Englezakis, A., Barlow, J. L., Hams, E., Scanlon, S. T., Ogg, G. S., Fallon, P. G., and McKenzie, A. N.J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Immunity |
Publisher: | Cell Press |
ISSN: | 1074-7613 |
ISSN (Online): | 1097-4180 |
Published Online: | 31 July 2014 |
Copyright Holders: | Copyright © 2014 The Authors |
First Published: | First published in Immunity 41(2):283-295 |
Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record