Inter- and intramolecular hydrogen bonding in phenol derivatives: a model system for poly-l-tyrosine

Hunt, N. T., Turner, A. R. and Wynne, K. (2005) Inter- and intramolecular hydrogen bonding in phenol derivatives: a model system for poly-l-tyrosine. Journal of Physical Chemistry B, 109(40), pp. 19008-19017. (doi:10.1021/jp052964o)

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Publisher's URL: http://dx.doi.org/10.1021/jp052964o

Abstract

The ultrafast dynamics of solutions of phenol and two phenol derivativeshydroquinone (1,4-benzenediol) and pyrocatechol (1,2-benzenediol)have been studied with Optically Heterodyne-Detected Optical Kerr-Effect (OHD-OKE) spectroscopy. The solvents, methanol and acetonitrile, were selected to provide strong and weak solvent−solute hydrogen-bonding interactions, respectively, while pyrocatechol features an intramolecular hydrogen bond. Together these provide a series of model systems for polypeptides such as polytyrosine, which facilitate the direct study of inter- and intramolecular hydrogen bonding. A broad contribution to the Raman spectral density of the methanol solutions at frequencies between 150 and 300 cm-1 has been observed that is absent in acetonitrile. This contribution has been assigned to solvent−solute hydrogen-bond stretching vibrations. The OHD-OKE response of poly-l-tyrosine has been measured and was found to contain a similar contribution. Density functional theory geometry optimizations and normal mode calculations have been performed using the B3LYP hybrid functional and 6-311++G** basis set. These have yielded a complete assignment of the low-frequency Raman and far-infrared spectra of pyrocatechol for the first time, which has provided information on the nature of the intramolecular hydrogen bond of pyrocatechol.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wynne, Professor Klaas
Authors: Hunt, N. T., Turner, A. R., and Wynne, K.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Journal of Physical Chemistry B
Publisher:American Chemical Society
ISSN:1520-6106
ISSN (Online):1520-5207

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