Cerebral perfusion correlates of depressed mood

Ebmeier, K.P., Cavanagh, J.T. , Moffoot, A.P., Glabus, M.F., O'Carroll, R.E. and Goodwin, G.M. (1997) Cerebral perfusion correlates of depressed mood. British Journal of Psychiatry, 170(1), pp. 77-81. (doi: 10.1192/bjp.170.1.77)

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Abstract

BACKGROUND: The spontaneous diurnal variation of mood and other symptoms provides a substrate for the examination of the relationship between symptoms and regional brain activation in depression.<p></p> METHOD: Twenty unipolar depressed patients with diurnal variation of mood were examined at 8 a.m. and 8 p.m. with neuropsychological measures, clinical ratings and single photon emission tomography (SPET). Brain perfusion maps were spatially transformed into standard stereotactic space and compared pixel-by-pixel. A parametric (correlational) analysis was used to examine the relationship between symptom severity and brain perfusion, both between and within subjects.<p></p> RESULTS Global depression severity and an independent 'vital' depression factor were associated in subjects with increased perfusion in cingulate and other paralimbic areas. In addition there was a probable association between an increase in an anxious-depression factor and reduced frontal neocortical perfusion.<p></p> CONCLUSIONS: Depressive symptom changes are associated with metabolic changes in the cingulate gyrus and associated paralimbic structures.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cavanagh, Professor Jonathan
Authors: Ebmeier, K.P., Cavanagh, J.T., Moffoot, A.P., Glabus, M.F., O'Carroll, R.E., and Goodwin, G.M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
Journal Name:British Journal of Psychiatry
Publisher:Royal College of Psychiatrists
ISSN:0007-1250
ISSN (Online):1472-1465

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