Cerebral perfusion correlates of depressed mood

Ebmeier, K.P., Cavanagh, J.T., Moffoot, A.P., Glabus, M.F., O'Carroll, R.E. and Goodwin, G.M. (1997) Cerebral perfusion correlates of depressed mood. British Journal of Psychiatry, 170(1), pp. 77-81. (doi:10.1192/bjp.170.1.77)

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BACKGROUND: The spontaneous diurnal variation of mood and other symptoms provides a substrate for the examination of the relationship between symptoms and regional brain activation in depression.

METHOD: Twenty unipolar depressed patients with diurnal variation of mood were examined at 8 a.m. and 8 p.m. with neuropsychological measures, clinical ratings and single photon emission tomography (SPET). Brain perfusion maps were spatially transformed into standard stereotactic space and compared pixel-by-pixel. A parametric (correlational) analysis was used to examine the relationship between symptom severity and brain perfusion, both between and within subjects.

RESULTS Global depression severity and an independent 'vital' depression factor were associated in subjects with increased perfusion in cingulate and other paralimbic areas. In addition there was a probable association between an increase in an anxious-depression factor and reduced frontal neocortical perfusion.

CONCLUSIONS: Depressive symptom changes are associated with metabolic changes in the cingulate gyrus and associated paralimbic structures.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Cavanagh, Professor Jonathan
Authors: Ebmeier, K.P., Cavanagh, J.T., Moffoot, A.P., Glabus, M.F., O'Carroll, R.E., and Goodwin, G.M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
Journal Name:British Journal of Psychiatry
Publisher:Royal College of Psychiatrists
ISSN (Online):1472-1465

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