The immune responses to bacterial antigens encountered in vivo at mucosal surfaces

Dougan, G., Ghaem-Maghami, M., Pickard, D., Frankel, G., Douce, G. , Clare, S., Dunstan, S. and Simmons, C. (2000) The immune responses to bacterial antigens encountered in vivo at mucosal surfaces. Philosophical Transactions of the Royal Society B: Biological Sciences, 355(1397), pp. 705-712. (doi:10.1098/rstb.2000.0610)

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Abstract

Mammals have evolved a sophisticated immune system for handling antigens encountered at their mucosal surfaces. The way in which mucosally delivered antigens are handled influences our ability to design effective mucosal vaccines. Live attenuated derivatives of pathogens are one route towards the development of mucosal vaccines. However, some molecules, described as mucosal immunogens, are inherently immunogenic at mucosal surfaces. Studies on mucosal immunogens may facilitate the identification of common characteristics that contribute to mucosal immunogenicity and aid the development of novel, non–living mucosal vaccines and immunostimulators.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Douce, Dr Gillian
Authors: Dougan, G., Ghaem-Maghami, M., Pickard, D., Frankel, G., Douce, G., Clare, S., Dunstan, S., and Simmons, C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Philosophical Transactions of the Royal Society B: Biological Sciences
Publisher:The Royal Society
ISSN:0962-8436
ISSN (Online):1471-2970

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