Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins

Rappuoli, R., Pizza, M., Douce, G. and Dougan, G. (1999) Structure and mucosal adjuvanticity of cholera and Escherichia coli heat-labile enterotoxins. Immunology Today, 20(11), pp. 493-500. (doi: 10.1016/S0167-5699(99)01523-6)

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Abstract

Escherichia coli heat-labile enterotoxin and cholera toxin are potent mucosal immunogens and adjuvants in animal models. Non-toxic mutants retaining adjuvant activity are useful tools to dissect the mechanism of mucosal adjuvanticity and promising candidates for development of human vaccines and immunotherapy. Clinical trials are expected to proceed in the near future.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Douce, Dr Gillian
Authors: Rappuoli, R., Pizza, M., Douce, G., and Dougan, G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Immunology Today
Publisher:Elsevier
ISSN:0167-5699
ISSN (Online):1355-8242

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