Experimental Salmonella typhimurium — induced gastroenteritis

Stephen, J., Amin, I. I. and Douce, G. R. (1993) Experimental Salmonella typhimurium — induced gastroenteritis. In: Cabello, F.C., Hormaeche, C.E., Mastroeni, P. and Bonina, L. (eds.) Biology of Salmonella. Series: NATO ASI Series, 245. Springer US, pp. 199-209. ISBN 9781461362364 (doi:10.1007/978-1-4615-2854-8_23)

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Publisher's URL: http://dx.doi.org/10.1007/978-1-4615-2854-8_23

Abstract

The rising incidence of salmonellosis in developed countries has refuelled intensive research into the pathogenesis of disease caused by Salmonella spp. These organisms cause two types of disease in man — acute gastroenteritis and systemic typhoid disease — as well as other important infections in domestic animals. It is highly desirable therefore, that we seek to understand the detailed biological and biochemical mechanisms involved in the pathogenesis of disease caused by these organisms. The gains from fundamental studies could be twofold. First, a greater ability to control infection caused by such a wide-spread pathogen whose eradication from the food chain would seem to be an impracticable aspiration. Second, one would hope that deeper insights into the fundamental mechanisms of disease causation would help generate greater confidence in the use of live metabolically crippled Salmonellae as Salmonella vaccines (O’Callaghan et al., 1988) or as vectors for delivering extraneous immunogens (Charles and Dougan, 1990).

Item Type:Book Sections
Status:Published
Glasgow Author(s) Enlighten ID:Douce, Dr Gillian
Authors: Stephen, J., Amin, I. I., and Douce, G. R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Publisher:Springer US
ISBN:9781461362364

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