T1 measurement using a short acquisition period for quantitative cardiac applications

Higgins, D. M., Ridgway, J. P., Radjenovic, A. , Sivananthan, U. M. and Smith, M. A. (2005) T1 measurement using a short acquisition period for quantitative cardiac applications. Medical Physics, 32(6), p. 1738. (doi: 10.1118/1.1921668)

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Publisher's URL: http://dx.doi.org/10.1118/1.1921668


Myocardial signal intensity curves for myocardial perfusion studies may be made quantitative by the use of T1 measurements made after the first-pass of contrast agent. A short data acquisition method for T1 mapping is presented in which all data for each T1 map are acquired in a short breath hold, and the slice geometry and timing in the cardiac cycle exactly match that of the dynamic first-pass perfusion sequence. This allows accurate image registration of the T1 map with the first-pass series of images. The T1 method is based on varying the preparation-pulse delay time of a saturation recovery sequence, and in this implementation employs an ECG-triggered, single-shot, spoiled gradient echo technique with SENSE reconstruction. The method allows T1 estimates of three slices to be made in fifteen heartbeats. For a range of samples with T1 values equivalent to those found in the myocardium during the first-pass of contrast agent, T1 estimates were accurate to within 6%, and the variation between slices was 2% or less.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Radjenovic, Dr Aleksandra
Authors: Higgins, D. M., Ridgway, J. P., Radjenovic, A., Sivananthan, U. M., and Smith, M. A.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Medical Physics
Publisher:American Association of Physicists in Medicine

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