Anderson, E. L., Howe, L. D., Fraser, A., Callaway, M. P., Sattar, N. , Day, C., Tilling, K. and Lawlor, D. A. (2014) Weight trajectories through infancy and childhood and risk of non-alcoholic fatty liver disease in adolescence: the ALSPAC study. Journal of Hepatology, 61(3), pp. 626-632. (doi: 10.1016/j.jhep.2014.04.018)
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Abstract
Background and Aims: Adiposity is a key risk factor for NAFLD. Few studies have examined prospective associations of infant and childhood adiposity with subsequent NAFLD risk. We examined associations of weight-for-height trajectories from birth to age 10 with liver outcomes in adolescence, and assessed the extent to which associations are mediated through fat mass at the time of outcome assessment.<p></p> Methods: Individual trajectories of weight and height were estimated for participants in the Avon Longitudinal Study of Parents and Children using random-effects linear-spline models. Associations of birthweight (adjusted for birth length) and weight change (adjusted for length/height change) from 0–3 months, 3 months–1 y, 1–3 y, 3–7 y, and 7–10 y with ultrasound scan (USS) determined liver fat and stiffness, and serum alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transferase (GGT) at mean age 17.8 y were assessed with linear and logistic regressions. Mediation by concurrent fat mass was assessed with adjustment for fat mass at mean age 17.8 y.<p></p> Results: Birth weight was positively associated with liver stiffness and negatively with ALT and AST. Weight change from birth to 1 y was not associated with outcomes. Weight change from 1–3 y, 3–7 y, and 7–10 y was consistently positively associated with USS and blood-based liver outcomes. Adjusting for fat mass at mean age 17.8 y attenuated associations toward the null, suggesting associations are largely mediated by concurrent body fatness.<p></p> Conclusions: Greater rates of weight-for-height change between 1 y and 10 y are consistently associated with adverse liver outcomes in adolescence. These associations are largely mediated through concurrent fatness.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Sattar, Professor Naveed |
| Authors: | Anderson, E. L., Howe, L. D., Fraser, A., Callaway, M. P., Sattar, N., Day, C., Tilling, K., and Lawlor, D. A. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
| Journal Name: | Journal of Hepatology |
| Publisher: | Elsevier B.V. |
| ISSN: | 0168-8278 |
| ISSN (Online): | 1600-0641 |
| Copyright Holders: | Copyright © 2014 European Association for the Study of the Liver |
| First Published: | First published in the Journal of Hepatology 61(3):626-632 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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