Further evidence that a cartilage-pannus junction synovitis predilection is not a specific feature of rheumatoid arthritis

Rhodes, L.A., Conaghan, P., Radjenovic, A. , Grainger, A.J., Emery, P. and McGonagle, D. (2005) Further evidence that a cartilage-pannus junction synovitis predilection is not a specific feature of rheumatoid arthritis. Annals of the Rheumatic Diseases, 64(9), pp. 1347-1349. (doi: 10.1136/ard.2004.033688)

Abstract

Background: Qualitative differences in synovitis between the cartilage-pannus junction (CPJ) region and the adjoining suprapatellar pouch (SPP) have been reported in rheumatoid arthritis and the spondyloarthropathies.<p></p> Objective: To determine if the distribution of synovitis is the same in osteoarthritis (OA) using sensitive measures of inflammation derived from dynamic, contrast enhanced magnetic resonance imaging (DEMRI).<p></p> Methods: 20 subjects with established OA of the knee were recruited. Conventional MR images together with the DEMRI measurements were obtained. Areas of synovitis at the CPJ region and at a distant site in the SPP were calculated; differences in CPJ and SPP synovitis were determined using DEMRI parameters: the initial rate of contrast enhancement (IRE) and maximal enhancement (ME).<p></p> Results: The area of synovitis was significantly greater adjacent to the CPJ than in the SPP. IRE and ME measures were greater at the CPJ than the SPP.<p></p> Conclusions: The magnitude of synovitis at the CPJ is not disease-specific and applies across the spectrum of degenerative disease as well as inflammatory diseases.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Radjenovic, Dr Aleksandra
• Authors: Rhodes, L.A., Conaghan, P., Radjenovic, A., Grainger, A.J., Emery, P., and McGonagle, D.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Annals of the Rheumatic Diseases
• Publisher: BMJ Publishing Group
• ISSN: 0003-4967
• ISSN (Online): 1468-2060