Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties

Rzepecka, J. et al. (2014) Small molecule analogues of the immunomodulatory parasitic helminth product ES-62 have anti-allergy properties. International Journal for Parasitology, 44(9), pp. 669-674. (doi: 10.1016/j.ijpara.2014.05.001)

Abstract

ES-62, a glycoprotein secreted by the filarial nematode Acanthocheilonema viteae, exhibits anti-inflammatory properties by virtue of covalently attached phosphorylcholine moieties. Screening of a library of ES-62 phosphorylcholine-based small molecule analogues (SMAs) revealed that two compounds, termed 11a and 12b, mirrored the helminth product both in inhibiting mast cell degranulation and cytokine responses in vitro and in preventing ovalbumin-induced Th2-associated airway inflammation and eosinophil infiltration of the lungs in mice. Furthermore, the two SMAs inhibited neutrophil infiltration of the lungs when administered therapeutically. ES-62-SMAs 11a and 12b thus represent starting points for novel drug development for allergies such as asthma.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Harnett, Professor Margaret and Al-Riyami, Dr Lamyaa and Tay, Dr Hwee Kee and Rzepecka, Dr Justyna and Khalaf, Dr Abedawn and Suckling, Professor Colin and Coltherd, Dr Jennifer
• Authors: Rzepecka, J., Coates, M. L., Saggar, M., Al-Riyami, L., Coltherd, J., Tay, H. K., Huggan, J. K., Janicova, L., Khalaf, A. I., Siebeke, I., Suckling, C. J., Harnett, M. M., and Harnett, W.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity; College of Science and Engineering > School of Chemistry
• Journal Name: International Journal for Parasitology
• Publisher: Elsevier Ltd.
• ISSN: 0020-7519
• ISSN (Online): 1879-0135
• Copyright Holders: Copyright © 2014 The Authors
• First Published: First published in International Journal for Parasitology 44(9):669-674
• Publisher Policy: Reproduced under a Creative Commons License