The cat, the fly and the beetle - why genetics needs a semantic education

Padmanabhan, S. , Hastie, C., Sainsbury, C., McBride, M. W. , Connell, J. M. and Dominiczak, A. F. (2009) The cat, the fly and the beetle - why genetics needs a semantic education. International Journal of Semantic Computing, 3(1), pp. 77-90. (doi:10.1142/S1793351X09000665)

Full text not currently available from Enlighten.

Publisher's URL: http://dx.doi.org/10.1142/S1793351X09000665

Abstract

Major advances have been made in the understanding of the genetic basis of diseases since Mendel's publication of the results of plant breeding experiments in 1866. To date these advances have been largely confined to the monogenic disorders — caused by mutations in a single gene. The public-health implications of these advances is relatively limited. In this review we explore our current understanding of the genetic basis of human traits and the reasons why current theories may account for the difficulties in identifying the genes for common diseases. We then postulate that semantic computing may be rightly poised to help understand complex disease causation, and explore the efforts that have been made to date to develop the necessary technological approach to the problem.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Hastie, Dr Claire and Sainsbury, Dr Christopher and McBride, Dr Martin and Padmanabhan, Professor Sandosh and Dominiczak, Professor Anna and Connell, Professor John
Authors: Padmanabhan, S., Hastie, C., Sainsbury, C., McBride, M. W., Connell, J. M., and Dominiczak, A. F.
Subjects:Q Science > QH Natural history > QH426 Genetics
R Medicine > R Medicine (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:International Journal of Semantic Computing
Publisher:World Scientific Publishing
ISSN:1793-351X
ISSN (Online):1793-7108

University Staff: Request a correction | Enlighten Editors: Update this record