International union of basic and clinical pharmacology. LXVII. Recommendations for the recognition and nomenclature of g protein-coupled receptor heteromultimers

Pin, J.P. et al. (2007) International union of basic and clinical pharmacology. LXVII. Recommendations for the recognition and nomenclature of g protein-coupled receptor heteromultimers. Pharmacological Reviews, 59(1), pp. 5-13. (doi: 10.1124/pr.59.1.5)

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Abstract

G protein-coupled receptors (GPCRs) have long been considered to be monomeric membrane proteins. Although numerous recent studies have indicated that GPCRs can form multimeric complexes, the functional and pharmacological consequences of this phenomenon have remained elusive. With the discovery that the functional GABAB receptor is an obligate heterodimer and with the use of energy transfer technologies, it is now accepted that GPCRs can form heteromultimers. In some cases, specific properties of such heteromers not shared by their respective homomers have been reported. Although in most cases these properties have only been observed in heterologous expression systems, there are a few reports describing data consistent with such heteromultimeric GPCR complexes also existing in native tissues. The present article illustrates well-documented examples of such native multimeric complexes, lists a number of recommendations for recognition and acceptance of such multimeric receptors, and gives recommendations for their nomenclature.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Milligan, Professor Graeme
Authors: Pin, J.P., Neubig, R., Bouvier, M., Devi, L., Filizola, M., Javitch, J.A., Lohse, M.J., Milligan, G., Palczewski, K., Parmentier, M., and Spedding, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
Journal Name:Pharmacological Reviews
Publisher:American Society for Pharmacology and Experimental Therapeutics
ISSN:0031-6997
ISSN (Online):1521-0081
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
242491Quantitative Analysis of the Effects of Receptor and G-Protein Mutations and Polymorphisms on Signal InitiationGraeme MilliganMedical Research Council (MRC)G9811527Institute of Neuroscience and Psychology
242492Quantitative Analysis of the Effects of Receptor and G-Protein Mutations and Polymorphisms on Signal InitiationGraeme MilliganMedical Research Council (MRC)G9811527Institute of Neuroscience and Psychology
389781The quaternary structure of G-protein coupled receptors - implications for function drug design. Programme grant support renewalGraeme MilliganMedical Research Council (MRC)G9811527Institute of Neuroscience and Psychology