Investigating the micro-rheology of the vitreous humor using an optically trapped local probe

Watts, F., Tan, L. E., Wilson, C. G., Girkin, J. M., Tassieri, M. and Wright, A. J. (2013) Investigating the micro-rheology of the vitreous humor using an optically trapped local probe. Journal of Optics, 16(1), 015301. (doi:10.1088/2040-8978/16/1/015301)

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Abstract

We demonstrate that an optically trapped silica bead can be used as a local probe to measure the micro-rheology of the vitreous humor. The Brownian motion of the bead was observed using a fast camera and the micro-rheology determined by analysis of the time-dependent mean-square displacement of the bead. We observed regions of the vitreous that showed different degrees of viscoelasticity, along with the homogeneous and inhomogeneous nature of different regions. The motivation behind this study is to understand the vitreous structure, in particular changes due to aging, allowing more confident prediction of pharmaceutical drug behavior and delivery within the vitreous humor.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Girkin, Prof John and Tassieri, Dr Manlio
Authors: Watts, F., Tan, L. E., Wilson, C. G., Girkin, J. M., Tassieri, M., and Wright, A. J.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Journal of Optics
Publisher:Institute of Physics Publishing Ltd.
ISSN:2040-8978
ISSN (Online):2040-8986
Copyright Holders:Copyright © 2014 IOP Publishing Ltd.
First Published:First published in Journal of Optics 16(1):015301
Publisher Policy:Reproduced under a Creative Commons License

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