Bath, P.M.W. et al. (2014) Baseline characteristics of the 4011 patients recruited into the 'Efficacy of Nitric Oxide in Stroke' (ENOS) trial. International Journal of Stroke, 9(6), pp. 711-720. (doi: 10.1111/ijs.12308)
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Abstract
Background: High blood pressure is common in acute stroke and associated with a worse functional outcome. Many patients who present with acute stroke are taking prescribed antihypertensive therapy before their stroke.<p></p> Aims: ENOS tested whether lowering blood pressure and continuing pre-stroke antihypertensive therapy are each safe and effective.<p></p> Methods: This study is an international multi-centre prospective randomized single-blind blinded-endpoint parallel-group partial-factorial controlled trial of transdermal glyceryl trinitrate (a nitric oxide donor, given for seven-days) vs. no glyceryl trinitrate, and of continuing vs. stopping (temporarily for seven-days) pre-stroke antihypertensive drugs if relevant, in patients with acute ischaemic stroke or intracerebral haemorrhage and high systolic blood pressure (140–220 mmHg).<p></p> Results: Recruitment ran from July 2001 to October 2013. Four thousand eleven patients [2097 (52·3%) in the continue/stop arm] were recruited from 173 sites across 23 countries in 5 continents (Asia 14%, Continental Europe 16%, UK 64%). Baseline characteristics include: mean age 70 (standard deviation 12) years; male 57%; mean time from stroke to recruitment 26 (13) h; mean severity (Scandinavian Stroke Scale) 34 (13) of 58; mean blood pressure 167 (19)/90 (13) mmHg; ischaemic stroke 83%; and intracerebral haemorrhage 16%. The main trial results will be presented in May 2014. The results will also be presented in updated Cochrane systematic reviews and included in individual patient data meta-analyses of all relevant randomized controlled trials.<p></p> Conclusion: ENOS is a large completed international trial of blood pressure management in acute stroke and includes patients representative of many stroke services worldwide.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Lees, Professor Kennedy |
Authors: | Bath, P.M.W., Adami, A., Bereczki, D., Berge, E., Beridze, M., Cala, L., Casado, A.,, Caso, V.,, Chang, H.M., Christensen, H., Collins, R., Czlonkowska, A., Dineen, R.A., El Etribi, A., Ghani, A.R., Gommans, J., Koumellis, P., Laska, A.C., Lees, K.R., Navarro, J., Ntaios, G., Ozturk, S., Phillips, S., Pocock, S., Prasad, K., Scutt, P., de Silva, H.A., Szatmari, S., Diez-Tejedor, E., Utton, S., Wang, Y., Wardlaw, J.M., Whynes, D., Wong, L., Woodhouse, L., and Sprigg, N. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | International Journal of Stroke |
Publisher: | Wiley-Blackwell Publishing Ltd. |
ISSN: | 1747-4930 |
ISSN (Online): | 1747-4949 |
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