Cardiovascular morbidity and mortality after kidney transplantation

Stoumpos, S., Jardine, A. G. and Mark, P. B. (2015) Cardiovascular morbidity and mortality after kidney transplantation. Transplant International, 28(1), pp. 10-21. (doi:10.1111/tri.12413) (PMID:25081992)

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Abstract

Kidney transplantation is the optimal treatment for patients with end stage renal disease (ESRD) who would otherwise require dialysis. Patients with ESRD are at dramatically increased cardiovascular (CV) risk compared to the general population. As well as improving quality of life, successful transplantation accords major benefits by reducing cardiovascular risk in these patients. Worldwide, cardiovascular disease remains the leading cause of death with a functioning graft and therefore is a leading cause of graft failure. This review focuses on the mechanisms underpinning excess cardiovascular morbidity and mortality and current evidence for improving cardiovascular risk in kidney transplant recipients. Conventional cardiovascular risk factors such as hypertension, diabetes mellitus, dyslipidaemia, and pre-existing ischaemic heart disease are all highly prevalent in this group. In addition, kidney transplant recipients exhibit a number of risk factors associated with pre-existing renal disease. Furthermore, complications specific to transplantation may ensue includingreduced graft function, side effects of immunosuppression and post transplantation diabetes mellitus. Strategies to improve cardiovascular outcomes post transplantation may include pharmacological intervention including lipid lowering or antihypertensive therapy, optimisation of graft function, lifestyle intervention and personalising immunosuppression to the individual patients risk profile.

Item Type:Articles
Additional Information:This is the accepted version of the following article: Stoumpos, S., Jardine, A. G., and Mark, P. B. Cardiovascular morbidity and mortality after kidney transplantation. Transplant International, which has been published in final form at http://dx.doi.org/10.1111/tri.12413
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Mark, Dr Patrick and Stoumpos, Dr Sokratis and Jardine, Professor Alan
Authors: Stoumpos, S., Jardine, A. G., and Mark, P. B.
Subjects:R Medicine > RC Internal medicine
R Medicine > RD Surgery
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Transplant International
Publisher:John Wiley & Sons Ltd
ISSN:0934-0874
ISSN (Online):1432-2277
Published Online:31 July 2014
Copyright Holders:Copyright © 2014 Steunstichting ESOT
First Published:First published in Transplant International 28(1):10-21
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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