NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery

Barry, G. et al. (2014) NSs protein of Schmallenberg virus counteracts the antiviral response of the cell by inhibiting its transcriptional machinery. Journal of General Virology, 95(Pt. 8), pp. 1640-1646. (doi:10.1099/vir.0.065425-0)

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Abstract

Bunyaviruses have evolved a variety of strategies to counteract the antiviral defence systems of mammalian cells. Here we show that the NSs protein of Schmallenberg virus (SBV) induces the degradation of the RPB1 subunit of RNA polymerase II and consequently inhibits global cellular protein synthesis and the antiviral response. In addition, we show that the SBV NSs protein enhances apoptosis in vitro and possibly in vivo, suggesting that this protein could be involved in SBV pathogenesis in different ways.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Schnettler, Dr Esther and Caporale, Dr Marco and Blomstrom, Dr Anne-Lie and Ratinier, Dr Maxime and Palmarini, Professor Massimo and Kohl, Professor Alain and Barry, Dr Gerald and Varela, Dr Mariana
Authors: Barry, G., Varela, M., Ratinier, M., Blomstrom, A.-L., Caporale, M., Seehusen, F., Hahn, K., Schnettler, E., Baumgartner, W., Kohl, A., and Palmarini, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of General Virology
Publisher:Society for General Microbiology
ISSN:0022-1317
ISSN (Online):1465-2099
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in Journal of General Virology 95(Pt.8):1640-1646
Publisher Policy:Reproduced under a Creative Commons License
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