The role of viral evolution in rabies host shifts and emergence

Mollentze, N., Biek, R. and Streicker, D. G. (2014) The role of viral evolution in rabies host shifts and emergence. Current Opinion in Virology, 8, pp. 68-72. (doi:10.1016/j.coviro.2014.07.004) (PMID:25064563) (PMCID:PMC4199325)

[img]
Preview
Text
96008.pdf - Published Version
Available under License Creative Commons Attribution.

440kB

Abstract

Despite its ability to infect all mammals, Rabies virus persists in numerous species-specific cycles that rarely sustain transmission in alternative species. The determinants of these species-associations and the adaptive significance of genetic divergence between host-associated viruses are poorly understood. One explanation is that epidemiological separation between reservoirs causes neutral genetic differentiation. Indeed, recent studies attributed host shifts to ecological factors and selection of ‘preadapted’ viral variants from the existing viral community. However, phenotypic differences between isolates and broad scale comparative and molecular evolutionary analyses indicate multiple barriers that Rabies virus must overcome through adaptation. This review assesses various lines of evidence and proposes a synthetic hypothesis for the respective roles of ecology and evolution in Rabies virus host shifts.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Streicker, Dr Daniel and Biek, Dr Roman and Mollentze, Mr Theodorus
Authors: Mollentze, N., Biek, R., and Streicker, D. G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:Current Opinion in Virology
Publisher:Elsevier Ltd.
ISSN:1879-6257
ISSN (Online):1879-6265
Copyright Holders:Copyright © 2014 The Authors
First Published:First published in Current Opinion in Virology 8:68-72
Publisher Policy:Reproduced under a Creative Commons License

University Staff: Request a correction | Enlighten Editors: Update this record

Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
634192Managing viral emergence at the interface of bats and livestockDaniel StreickerWellcome Trust (WELLCOME)102507/Z/13/ZRI BIODIVERSITY ANIMAL HEALTH & COMPMED