Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris

Navarini, A. A. et al. (2014) Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris. Nature Communications, 5, p. 4020. (doi: 10.1038/ncomms5020)

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Publisher's URL: http://dx.doi.org/10.1038/ncomms5020

Abstract

Acne vulgaris (acne) is a common inflammatory disorder of the cutaneous pilo-sebaceous unit. Here we perform a genome-wide association analysis in the United Kingdom, comparing severe cases of acne (n=1,893) with controls (n=5,132). In a second stage, we genotype putative-associated loci in a further 2,063 acne cases and 1,970 controls. We identify three genome-wide significant associations: 11q13.1 (rs478304, Pcombined=3.23 × 10−11, odds ratio (OR)=1.20), 5q11.2 (rs38055, Pcombined=4.58 × 10−9, OR=1.17) and 1q41 (rs1159268, Pcombined=4.08 × 10−8, OR=1.17). All three loci contain genes linked to the TGFβ cell signalling pathway, namely OVOL1, FST and TGFB2. Transcripts of OVOL1 and TFGB2 have decreased expression in affected compared with normal skin. Collectively, these data support a key role for dysregulation of TGFβ-mediated signalling in susceptibility to acne.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Burden, Professor David
Authors: Navarini, A. A., Simpson, M. A., Weale, M., Knight, J., Carlavan, I., Reiniche, P., Burden, D. A., Layton, A., Bataille, V., Allen, M., Pleass, R., Pink, A., Creamer, D., English, J., Munn, S., Walton, S., Akhras, V., Alexandroff, A., Anstey, A., Azad, J., Aziz, O., Baudry, D., Burrows, N., Butt, A., Cartwright, P., Chapman, A., Clayton, T., Cliff, S., Cunliffe, W., Cutler, T., Daly, B., Damian, E., Darvay, A., DeGiovanni, C., Downs, A., Duckworth, M., Dwyer, C., Ferguson, A., Fleming, C., Fox, Z., Frazer-Andrews, E., Gonzalez, J., Goodfield, M., Graham, R., Grattan, C., Green, N., Hazelwood-Smith, S., Hempel, H., Hood, S., Hughes, B., Ladoyanni, E., Lyon, C., Mahmud, A., Malik, M., Meggitt, S., Messenger, A., Moosa, Y., Ormerod, A., Patel, V., Rallan, D., Robertson, S., Ross, J., Salvary, I., Wachsmuth, R., Wahie, S., Williamson, D., Willis, C., Déret, S., Voegel, J. J., Spector, T., Smith, C. H., Trembath, R. C., and Barker, J. N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Nature Communications
Publisher:Nature Publishing Group
ISSN:2041-1723

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