Lo Re, D., Zhou, Y., Nobis, M., Anderson, K. I. and Murphy, P. V. (2014) Synthesis of migrastatin and its macroketone analogue and in vivo FRAP analysis of the macroketone on E-cadherin dynamics. ChemBioChem, 15(10), pp. 1459-1464. (doi: 10.1002/cbic.201402061)
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Publisher's URL: http://dx.doi.org/10.1002/cbic.201402061
Abstract
An efficient and scalable synthesis of a key acyclic intermediate used for the preparation of migrastatin and its macroketone analogue is described; Brown alkoxyallylation is the key step for this synthesis. The macroketone was prepared on 100 mg scale by this route. Treatment of invasive pancreatic cancer cells grown on a cell-derived matrix or as subcutaneous tumours in nude mice with the macroketone inhibited E-cadherin dynamics in a manner consistent with increased cell adhesion and reduced invasive potential.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Anderson, Professor Kurt and Nobis, Mr Max |
| Authors: | Lo Re, D., Zhou, Y., Nobis, M., Anderson, K. I., and Murphy, P. V. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
| Journal Name: | ChemBioChem |
| Publisher: | Wiley |
| ISSN: | 1439-4227 |
| ISSN (Online): | 1439-7633 |
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