Mapping pathways to drug resistance with proteomics

Burchmore, R. (2014) Mapping pathways to drug resistance with proteomics. Expert Review of Proteomics, 11(1), pp. 1-3. (doi:10.1586/14789450.2014.871497)

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Abstract

Emerging drug resistance thwarts progress in chemotherapy, resulting in increased morbidity, mortality and healthcare costs. Understanding the mechanisms by which drug resistance phenotypes emerge is important to prolong the useful life of existing drugs but may also highlight pathways that play a role in the acquisition of resistance and which may themselves present resistance-proof drug targets. Comparative proteomic approaches have demonstrated potential to link drug resistance phenotypes to molecular changes but will also prove powerful in the elucidation of the mechanisms by which drug resistance arises.

Item Type:Articles (Editorial)
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Burchmore, Dr Richard
Authors: Burchmore, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Expert Review of Proteomics
Publisher:Expert Reviews
ISSN:1478-9450
ISSN (Online):1744-8387

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