QTc and sudden cardiac death

Brown, C. and Padmanabhan, S. (2014) QTc and sudden cardiac death. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 779-806. ISBN 9780123868831 (doi:10.1016/B978-0-12-386882-4.00033-5)

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Publisher's URL: http://dx.doi.org/10.1016/B978-0-12-386882-4.00033-5

Abstract

Long QT syndrome (LQTS) is characterized by abnormal prolongation of the QT interval on the surface electrocardiogram associated with risk of polymorphic ventricular arrhythmia, torsades de pointes (TdP), and sudden cardiac death. Causes of LQTS may be congenital (e.g. autosomal dominant Romano-Ward syndrome) or acquired upon exposure to environmental triggers such as particular medications. Increasing numbers of causative mutations for congenital LQTS have been identified. Drugs are the commonest cause of acquired LQTS and it is thought that there is also a significant heritable component to drug-induced LQTS. Over the years, several drugs have been withdrawn due to QT prolongation and arrhythmia.<p></p> Here we discuss LQTS, its public health implications, future directions and perspectives including pharmacogenomic studies and new drug development. More detailed characterization of the genetics of congenital and drug-induced LQTS will allow improved evaluation of personalized risk, and better inform patient management in the future.

Item Type:Book Sections
Status:Published
Refereed:No
Glasgow Author(s) Enlighten ID:Brown, Dr Catriona and Padmanabhan, Professor Sandosh
Authors: Brown, C., and Padmanabhan, S.
Subjects:R Medicine > RM Therapeutics. Pharmacology
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Handbook of Pharmacogenomics and Stratified Medicine
Publisher:Academic Press
ISBN:9780123868831
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