Pharmacodynamic pharmacogenomics

McCallum, L., Lip, S. and Padmanabhan, S. (2014) Pharmacodynamic pharmacogenomics. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 365-383. ISBN 9780123868831 (doi:10.1016/B978-0-12-386882-4.00018-9)

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Publisher's URL: http://dx.doi.org/10.1016/B978-0-12-386882-4.00018-9

Abstract

The fundamental assumption of pharmacology is that a relationship exists between a drug’s effect and its concentration. Pharmacodynamics is the study of the physiological and molecular effects that drugs exert on their recipients and the relationship between plasma drug concentration and drug effect. The therapeutic and adverse effects of drugs result from their interaction with the recipient’s molecular components, which cause biochemical and physiological changes in the recipient that are characterized as a drug’s response. An individual’s response to a given drug depends on a complex interplay between environmental and genetic factors.<p></p> Individual variability and genetic polymorphism may result in altered drug efficacy, an increased susceptibility to adverse drug reactions, or protection from adverse drug reactions. Pharmacodynamic pharmacogenomics is the study of altered response to drugs associated with genetic polymorphisms of genes encoding for drug targets and associated modifiers or key proteins. To highlight the growing importance of pharmacodynamic factors in pharmacogenomic-directed therapeutics, examples are given of the genetic variability of drug targets leading to altered drug response.

Item Type:Book Sections
Status:Published
Glasgow Author(s) Enlighten ID:Lip, Miss Stefanie and Padmanabhan, Professor Sandosh
Authors: McCallum, L., Lip, S., and Padmanabhan, S.
Subjects:R Medicine > RM Therapeutics. Pharmacology
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Publisher:Academic Press
ISBN:9780123868831
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