Alsanosi, S. M. M., Skiffington, C. and Padmanabhan, S. (2014) Pharmacokinetic pharmacogenomics. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 341-364. ISBN 9780123868831 (doi: 10.1016/B978-0-12-386882-4.00017-7)
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Publisher's URL: http://dx.doi.org/10.1016/B978-0-12-386882-4.00017-7
Abstract
Pharmacokinetics (PK) is the branch of pharmacology that deals with the absorption, distribution, and elimination of drugs. Since the 1950s there have been major advances in understanding the genetic basis of the interindividual variability observed in the pharmacokinetics, efficacy, and toxicity of some drugs. Pharmacokinetic pharmacogenetics feature in an increasing number of drug labels approved by the FDA. The main aim of this chapter is to provide a basic introduction to pharmakinetic principles and to summarize the progress in the pharmacogenomics of key pharmacokinetic systems.
Item Type: | Book Sections |
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Status: | Published |
Glasgow Author(s) Enlighten ID: | Padmanabhan, Professor Sandosh |
Authors: | Alsanosi, S. M. M., Skiffington, C., and Padmanabhan, S. |
Subjects: | R Medicine > RM Therapeutics. Pharmacology |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Publisher: | Academic Press |
ISBN: | 9780123868831 |
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