Fundamentals of complex trait genetics and association studies

Alghamdi, J. and Padmanabhan, S. (2014) Fundamentals of complex trait genetics and association studies. In: Padmanabhan, S. (ed.) Handbook of Pharmacogenomics and Stratified Medicine. Academic Press: London, pp. 235-257. ISBN 9780123868831 (doi: 10.1016/B978-0-12-386882-4.00012-8)

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Complex traits are multifactorial phenotypes and are the result of numerous genes, environmental factors, and their interactions. The genetic dissection of complex traits has accelerated recently with advances in genomic technologies. In pharmacogenomics, the complexity of the processes that affect drug response and toxicity makes the selection of the right phenotype for study challenging. Once the right phenotype is selected, the genetic contribution to the trait is estimated using familial aggregation and heritability studies. This is followed by established methods of linkage or association analysis to identify the genetic variant associated with the trait. This chapter outlines the basic principles of population genetics and the analytic methods used in relating DNA sequence variation to drug response.

Item Type:Book Sections
Glasgow Author(s) Enlighten ID:Padmanabhan, Professor Sandosh
Authors: Alghamdi, J., and Padmanabhan, S.
Subjects:R Medicine > RM Therapeutics. Pharmacology
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Publisher:Academic Press
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