Herpes simplex virus 1 infection upregulates stress protein expression in cultured retinal neurons

Kennedy, P. G. E., Wakakura, M., Foulds, W. S. and Clements, G. B. (1990) Herpes simplex virus 1 infection upregulates stress protein expression in cultured retinal neurons. Journal of Neurology, Neurosurgery and Psychiatry, 53(1), pp. 72-75. (doi: 10.1136/jnnp.53.1.72)

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Publisher's URL: http://dx.doi.org/10.1136/jnnp.53.1.72

Abstract

The production of a 57K stress protein (StrP) after herpes simplex virus type 1 (HSV-1) infection was examined in cultured neonatal rat retinal cells. StrP expression in individual cells was identified using a monoclonal antibody, TI56. Indirect immunofluorescence of uninfected retinal cultures showed that approximately 40% of cells expressed neurofilament (NF+) and 5% expressed a low level of StrP. Following HSV infection the proportion of NF+ cells decreased while the proportion of StrP positive cells became greater and the intensity of staining increased. The number of cells labelled with a polyclonal anti-HSV antibody increased with time after infection. Retinal neurons in culture can be infected with HSV, after which StrP expression is significantly upregulated.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kennedy, Professor Peter
Authors: Kennedy, P. G. E., Wakakura, M., Foulds, W. S., and Clements, G. B.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Neurology, Neurosurgery and Psychiatry
Publisher:BMJ Publishing Group
ISSN:0022-3050
ISSN (Online):1468-330X

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