Kennedy, P. G. E., Wakakura, M., Foulds, W. S. and Clements, G. B. (1990) Herpes simplex virus 1 infection upregulates stress protein expression in cultured retinal neurons. Journal of Neurology, Neurosurgery and Psychiatry, 53(1), pp. 72-75. (doi: 10.1136/jnnp.53.1.72)
Full text not currently available from Enlighten.
Publisher's URL: http://dx.doi.org/10.1136/jnnp.53.1.72
Abstract
The production of a 57K stress protein (StrP) after herpes simplex virus type 1 (HSV-1) infection was examined in cultured neonatal rat retinal cells. StrP expression in individual cells was identified using a monoclonal antibody, TI56. Indirect immunofluorescence of uninfected retinal cultures showed that approximately 40% of cells expressed neurofilament (NF+) and 5% expressed a low level of StrP. Following HSV infection the proportion of NF+ cells decreased while the proportion of StrP positive cells became greater and the intensity of staining increased. The number of cells labelled with a polyclonal anti-HSV antibody increased with time after infection. Retinal neurons in culture can be infected with HSV, after which StrP expression is significantly upregulated.
Item Type: | Articles |
---|---|
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Kennedy, Professor Peter |
Authors: | Kennedy, P. G. E., Wakakura, M., Foulds, W. S., and Clements, G. B. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Journal of Neurology, Neurosurgery and Psychiatry |
Publisher: | BMJ Publishing Group |
ISSN: | 0022-3050 |
ISSN (Online): | 1468-330X |
University Staff: Request a correction | Enlighten Editors: Update this record