Do patients with demyelinating disease have antibodies against human glial cells in their sera?

Kennedy, P. G. E. and Lisak, R. P. (1981) Do patients with demyelinating disease have antibodies against human glial cells in their sera? Journal of Neurology, Neurosurgery and Psychiatry, 44(2), pp. 164-167. (doi:10.1136/jnnp.44.2.164)

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Publisher's URL: http://dx.doi.org/10.1136/jnnp.44.2.164

Abstract

Cell-type-specific markers and indirect immunofluorescence were used to study immunoglobulin binding to glial cells in dissociated cell cultures of human foetal optic nerve, spinal cord and dorsal root ganglion in sera from patients with demyelinating diseases, other neurological diseases and normal controls. These various sera proved to be indistinguishable in that almost all of them contained immunoglobulin which bound weakly to all oligodendrocytes and fibroblasts, 5-25% of astrocytes and about 50% of Schwann cells.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kennedy, Professor Peter
Authors: Kennedy, P. G. E., and Lisak, R. P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Neurology, Neurosurgery and Psychiatry
Publisher:BMJ Publishing Group
ISSN:0022-3050
ISSN (Online):1468-330X

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