Human African trypanosomiasis of the CNS: current issues and challenges

Kennedy, P. G.E. (2004) Human African trypanosomiasis of the CNS: current issues and challenges. Journal of Clinical Investigation, 113(4), pp. 496-504. (doi: 10.1172/JCI21052)

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Publisher's URL: http://dx.doi.org/10.1172/JCI21052

Abstract

Human African trypanosomiasis (HAT), also known as sleeping sickness, is a major cause of mortality and morbidity in sub-Saharan Africa. Current therapy with melarsoprol for CNS HAT has unacceptable side-effects with an overall mortality of 5%. This review discusses the issues of diagnosis and staging of CNS disease, its neuropathogenesis, and the possibility of new therapies for treating late-stage disease.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kennedy, Professor Peter
Authors: Kennedy, P. G.E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Clinical Investigation
Publisher:Americal Society for Clinical Investigation
ISSN:0021-9738
ISSN (Online):1558-8238
Copyright Holders:Copyright © 2004 Americal Society for Clinical Investigation
First Published:First published in Journal of Clinical Investigation 113(4):496-504
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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