Kennedy, P. G.E. (2004) Human African trypanosomiasis of the CNS: current issues and challenges. Journal of Clinical Investigation, 113(4), pp. 496-504. (doi: 10.1172/JCI21052)
|
Text
95517.pdf - Published Version 5MB |
Publisher's URL: http://dx.doi.org/10.1172/JCI21052
Abstract
Human African trypanosomiasis (HAT), also known as sleeping sickness, is a major cause of mortality and morbidity in sub-Saharan Africa. Current therapy with melarsoprol for CNS HAT has unacceptable side-effects with an overall mortality of 5%. This review discusses the issues of diagnosis and staging of CNS disease, its neuropathogenesis, and the possibility of new therapies for treating late-stage disease.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Kennedy, Professor Peter |
| Authors: | Kennedy, P. G.E. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
| Journal Name: | Journal of Clinical Investigation |
| Publisher: | Americal Society for Clinical Investigation |
| ISSN: | 0021-9738 |
| ISSN (Online): | 1558-8238 |
| Copyright Holders: | Copyright © 2004 Americal Society for Clinical Investigation |
| First Published: | First published in Journal of Clinical Investigation 113(4):496-504 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details