Antisera to bovine oligodendroglia raised in guinea pigs bind to surface of rat oligodendroglia and Schwann cells

Lisak, R.P., Pruss, R. M., Kennedy, P.G.E., Abramsky, O., Pleasure, D.E. and Silberberg, D.H. (1980) Antisera to bovine oligodendroglia raised in guinea pigs bind to surface of rat oligodendroglia and Schwann cells. Neuroscience Letters, 17(1-2), pp. 119-124. (doi:10.1016/0304-3940(80)90072-5)

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Publisher's URL: http://dx.doi.org/10.1016/0304-3940(80)90072-5

Abstract

Antisera against bulk isolated bovine oligodendrocytes was raised in 2 guinea pigs (GPaBO). The sera bound only to surface of rat oligodendrocytes in dissociated rat corpus callosum and cerebellar cultures and only to surface of Schwann cells in primary and secondary sciatic nerve and dorsal root ganglia cultures as determined by indirect immunofluorescence. No cells in muscle or retinal cultures bound the guinea pig antisera. The shared antigen does not seem to be either galactocerebroside (GalC) or a myelin basic protein. GPaBO can serve as a useful marker in double-label experiments to identify oligodendrocytes and Schwann cells in dissociated cultures.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kennedy, Professor Peter
Authors: Lisak, R.P., Pruss, R. M., Kennedy, P.G.E., Abramsky, O., Pleasure, D.E., and Silberberg, D.H.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Neuroscience Letters
Publisher:Elsevier
ISSN:0304-3940
ISSN (Online):1872-7972

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