EAE, EAN and galactocerebroside sera bind to oligodendrocytes and Schwann cells

Lisak, R. P., Saida, T., Kennedy, P. G.E., Saida, K., Silberberg, D. H. and Leibowitz, S. (1980) EAE, EAN and galactocerebroside sera bind to oligodendrocytes and Schwann cells. Journal of the Neurological Sciences, 48(2), pp. 287-296. (doi:10.1016/0022-510X(80)90207-5)

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Publisher's URL: http://dx.doi.org/10.1016/0022-510X(80)90207-5

Abstract

Sera from rabbits with EAN induced by sensitization with galactocerebroside (GalC-EAN) bound to the surface of Schwann cells and oligodendrocytes in rat nervous system dispersion cultures. Sera from rabbits with bovine femoral nerve-induced EAN (FN-EAN) bound to Schwann cells, oligodendroglia and occasional fibroblasts. Sera from animals with bovine spinal cord-induced EAE (SC-EAE) bound to these cells and to some astrocytes as well. Absorption of the capacity to bind to oligodendroglia and Schwann cells suggests that GalC is the major, if not the only surface antigen on these two cell types to which these sera bind. The capacity of GalC-EAN, SC-EAE, and FN-EAN sera to bind to the surface of the cells responsible for myelin synthesis in both PNS and CNS correlates with the ability of these sera to cause both PNS and CNS demyelination in vitro and PNS demyelination in vivo.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Kennedy, Professor Peter
Authors: Lisak, R. P., Saida, T., Kennedy, P. G.E., Saida, K., Silberberg, D. H., and Leibowitz, S.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of the Neurological Sciences
Publisher:Elsevier
ISSN:0022-510X
ISSN (Online):1878-5883

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