Intestinal macrophages and dendritic cells: what's the difference?

Cerovic, V., Bain, C. C., Mowat, A. M. and Milling, S. W.F. (2014) Intestinal macrophages and dendritic cells: what's the difference? Trends in Immunology, 35(6), pp. 270-277. (doi:10.1016/j.it.2014.04.003)

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Abstract

Mononuclear phagocytes (MPs) in the murine intestine, comprising dendritic cells (DCs) and macrophages (Mϕs), perform disparate yet complementary immunological functions. Functional analyses of these distinct MP subsets have been complicated by the substantial overlap in their surface phenotypes. Here, we review recent findings that have enabled more accurate definition of these MP subsets. We discuss these recent advances in the context of the current understanding of the functions of DCs and Mϕs in the maintenance of intestinal homeostasis, and how their functions may alter when homeostasis is disrupted.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Milling, Professor Simon and Mowat, Professor Allan and Cerovic, Dr Vuk and Bain, Mr Calum
Authors: Cerovic, V., Bain, C. C., Mowat, A. M., and Milling, S. W.F.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Trends in Immunology
Publisher:Elsevier Ltd.
ISSN:1471-4906
ISSN (Online):1471-4981

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