Recto-anal motility responses in the Göttingen minipig to selective stimulation of the ventral sacral nerve roots

Andersen, I.S., Rijkhoff, N.J.M., Vuckovic, A., Buntzen, S. and Djurhuus, J.C. (2002) Recto-anal motility responses in the Göttingen minipig to selective stimulation of the ventral sacral nerve roots. Scandinavian Journal of Gastroenterology, 37(235), p. 26. (doi:10.1080/00365520260080111)

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Publisher's URL: http://dx.doi.org/10.1080/00365520260080111

Abstract

Introduction: Following spinal cord injury control of normal bowel activities is lost, leading to constipation associated with episodic faecal impaction and overflow faecal incontinence. Rectal evacuation might improve if the rectum could be activated by selective stimulation of the ventral sacral nerve roots (VSNR) without activation of the external anal sphincter (EAS).

Aim: The aim was to investigate whether selective activation of the rectum, without activation of the EAS, can be obtained by selective stimulation of the VSNR (S2 -S3 ).

Methods and material: The recto-anal motility response to electrical stimulation was investigated in 7 alpha-1-chloralose anaesthetised pigs. Stimulation was accomplished through cuff-electrodes placed on the intradural VSNR. Anal pressure and rectal motility were recorded by manometry and impedance planimetry, respectively.

Results: Unilateral stimulation of the S2 (n=4) or S3 (n=3) roots with trains of short duration pulses at low as wel as high amplitude resulted in a contraction of the EAS. Using trains of long duration pulses, anodal blocking was achieved in all pigs resulting in an anal pressure response, which was reduced more than 80% compared to stimulation without blocking. In 3 pigs rectal responses were obtained.

Conclusion: The results of this study demonstrate that selective activation of the rectum, with reduced activation of the EAS is feasible when stimulating the VSNR.

Item Type:Articles
Additional Information:The XXXIV Nordic Meeting of Gastroenterology
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Vuckovic, Dr Aleksandra
Authors: Andersen, I.S., Rijkhoff, N.J.M., Vuckovic, A., Buntzen, S., and Djurhuus, J.C.
College/School:College of Science and Engineering > School of Engineering > Biomedical Engineering
Journal Name:Scandinavian Journal of Gastroenterology
Publisher:Informa Healthcare
ISSN:0036-5521
ISSN (Online):1502-7708

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