Sbrana, S., Marchetti, V., Mancianti, F., Guidi, G. and Bennett, D. (2014) Retrospective study of 14 cases of canine arthritis secondary to Leishmaniainfection. Journal of Small Animal Practice, 55(6), pp. 309-313. (doi: 10.1111/jsap.12204)
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Abstract
OBJECTIVE: To describe the clinical appearance, laboratory findings and response to treatment of dogs with inflammatory joint disease associated with Leishmania infection.<p></p> METHODS: Retrospective analysis of case records of dogs with serologically confirmed leishmaniasis and concurrent inflammatory joint disease presented between 2005 and 2011.<p></p> RESULTS: In total, 14 cases met the inclusion criteria. Of these, five (36%) dogs were presented with monoarthritis, five (36%) with oligoarthritis and four (28%) with polyarthritis. The most frequently affected joint was the carpus. Both erosive and non-erosive disease was identified on radiographic examination. All dogs had an inflammatory synovial fluid with a high white cell count and a preponderance of neutrophils, and in eight (57%) cases Leishmania amastigotes were found in the synovial fluid smears.<p></p> Dogs were treated with 50 mg/kg N-methylglucamine antimoniate twice a day for 1 month and 10 mg/kg allopurinol twice a day for 6 to 9 months combined with prednisolone in five cases. At the 6-month follow-up, eight (57%) dogs showed improvement in general and orthopaedic signs and four (28%) dogs were stable.<p></p> CLINICAL SIGNIFICANCE: Leishmaniasis should be considered a differential diagnosis in dogs with inflammatory arthritis in endemic areas.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Bennett, Professor David |
Authors: | Sbrana, S., Marchetti, V., Mancianti, F., Guidi, G., and Bennett, D. |
College/School: | College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
Journal Name: | Journal of Small Animal Practice |
Publisher: | Wiley-Blackwell Publishing Ltd. |
ISSN: | 0022-4510 |
ISSN (Online): | 1748-5827 |
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