Epigenesis: roles of nanotopography, nanoforces and nanovibration

Curtis, A. S. and Tsimbouri, P. M. (2014) Epigenesis: roles of nanotopography, nanoforces and nanovibration. Expert Review of Medical Devices, 11(4), pp. 417-423. (doi: 10.1586/17434440.2014.916205)

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We consider three biophysical factors operating at the nanoscale which can affect gene expression, and thus, differentiation, in cultured mammalian cells. These factors are nanovibration, nanoforces and the local nanotopography. Work supporting these conclusions is reviewed. It is argued that stirring of the medium close to the cells cannot contribute to the effects. It is suggested that the three factors interact. Possible pathways by which this could occur are outlined.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Curtis, Professor Adam and Tsimbouri, Dr Monica
Authors: Curtis, A. S., and Tsimbouri, P. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Molecular Cell and Systems Biology
Journal Name:Expert Review of Medical Devices
Publisher:Expert Reviews Ltd.
ISSN (Online):1745-2422
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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
593571Manipulation of cancer cells by nanotopography: strategies to control migration, proliferation and apoptosis (ISSF Catalyst Fund)Penelope TsimbouriWellcome Trust (WELLCOME)097821/Z/11/ZRI MOLECULAR CELL & SYSTEMS BIOLOGY