Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11)

Cockeran, R., Herbert, J. A., Mitchell, T. J., Dix-Peek, T., Dickens, C., Anderson, R. and Feldman, C. (2014) Exposure of a 23F serotype strain of Streptococcus pneumoniae to cigarette smoke condensate is associated with selective upregulation of genes encoding the two-component regulatory system 11 (TCS11). BioMed Research International, 2014, p. 976347. (doi: 10.1155/2014/976347)

Abstract

Alterations in whole genome expression profiles following exposure of the pneumococcus (strain 172, serotype 23F) to cigarette smoke condensate (160 μg/mL) for 15 and 60 min have been determined using the TIGR4 DNA microarray chip. Exposure to CSC resulted in the significant (P < 0.014–0.0006) upregulation of the genes encoding the two-component regulatory system 11 (TCS11), consisting of the sensor kinase, hk11, and its cognate response regulator, rr11, in the setting of increased biofilm formation. These effects of cigarette smoke on the pneumococcus may contribute to colonization of the airways by this microbial pathogen.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Herbert, Ms Jenny and Mitchell, Professor Timothy
• Authors: Cockeran, R., Herbert, J. A., Mitchell, T. J., Dix-Peek, T., Dickens, C., Anderson, R., and Feldman, C.
• College/School: College of Medical Veterinary and Life Sciences > School of Infection & Immunity
• Journal Name: BioMed Research International
• Publisher: Hindawi Publishing Corporation
• ISSN: 2314-6133
• ISSN (Online): 2314-6141
• Copyright Holders: Copyright © 2014 The Authors
• First Published: First published in BioMed Research International 2014:976347
• Publisher Policy: Reproduced under a Creative Commons License