Metabolic trafficking between cells in nervous tissue

Coles, J. A., Véga, C. and Marcaggi, P. (2000) Metabolic trafficking between cells in nervous tissue. In: Agnati, L. F., Fuxe, K., Nicholson, C. and Sykova, E. (eds.) Volume Transmission Revisited. Series: Progress in brain research, 125 (125). Elsevier, pp. 241-254. ISBN 9780444503145 (doi: 10.1016/S0079-6123(00)25014-0)

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There is evidence that two pathways of intercellular transfer of molecules between neurons and glial cells are quantitatively predominant in the mammalian brain. The first is the route, still unproven in the brain itself, but compatible with many experimental results, that transfers carbon fuel, starting as glucose in the capillaries, through astrocytes to neurons. This chapter discusses the main arguments in favor of its existence, most of which concern the role of lactate in aerobic metabolism and its possible transfer from astrocytes to neurons. The second pathway is the transfer of glutamate from neurons to astrocytes, and the transfer of glutamine in the opposite direction. For the glutamate-glutamine shuttle, the chapter concentrates on an apparent corollary of it, transfer of ammonium from neurons to astrocytes, which clearly falls within the concept of volume transmission.

Item Type:Book Sections
Glasgow Author(s) Enlighten ID:Coles, Dr Jonathan
Authors: Coles, J. A., Véga, C., and Marcaggi, P.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Progress in Brain Research

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