Conditions under which Na+channels can boost conduction of small graded potentials

Taylor, G. C., Coles, J. A. and Eilbeck, J. C. (1995) Conditions under which Na+channels can boost conduction of small graded potentials. Journal of Theoretical Biology, 172(4), pp. 379-386. (doi: 10.1006/jtbi.1995.0035)

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Publisher's URL: http://dx.doi.org/10.1006/jtbi.1995.0035

Abstract

It has recently become apparent that in the dendrites or short axons of some neurons, voltage-dependent sodium channels are used not to generate action potentials but to modulate graded potentials; graded potentials carry far more information than do action potentials. A model axon (or dendrite) is described in which sodium channels with kinetics described by equations of the Hodgkin-Huxley type boost conduction of small voltage signals. For a sodium channel density beyond a certain minimum there exists an optimal potential, depolarized with respect to the resting potential, at which there is no steady-state decrement along the axon. For an axon not longer than about 0.7 length constants, small, steady-state deviations from this optimal potential imposed at one end of the axon appear amplified in a graded and stable way at the other end. A small pulse of potential is propagated with amplification and more rapidly than in an axon with a passive membrane. Compared to passive propagation, there will be an improvement in signal-to-noise ratio at the synapse; the axon also acts as a selective frequency filter. The same axon is capable of conducting an action potential.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Coles, Dr Jonathan
Authors: Taylor, G. C., Coles, J. A., and Eilbeck, J. C.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Theoretical Biology
Publisher:Elsevier
ISSN:0022-5193
ISSN (Online):1095-8541

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