Highly efficient synthesis of the tricyclic core of Taxol by cascade metathesis

Letort, A., Aouzal, R., Ma, C., Long, D.-L. and Prunet, J. (2014) Highly efficient synthesis of the tricyclic core of Taxol by cascade metathesis. Organic Letters, 16(12), pp. 3300-3303. (doi: 10.1021/ol501304j)

Abstract

An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning of the dienyne precursor is performed.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Prunet, Dr Joelle and Long, Dr Deliang and Letort, Mr Aurelien
• Authors: Letort, A., Aouzal, R., Ma, C., Long, D.-L., and Prunet, J.
• College/School: College of Science and Engineering > School of Chemistry
• Journal Name: Organic Letters
• Journal Abbr.: Org. Lett.
• Publisher: American Chemical Society
• ISSN: 1523-7060
• ISSN (Online): 1523-7052
• Copyright Holders: Copyright © 2014 2014 American Chemical Society
• First Published: First published in Organic Letters 16(12):330-3303
• Publisher Policy: Reproduced in accordance with the copyright policy of the publisher