Highly efficient synthesis of the tricyclic core of Taxol by cascade metathesis

Letort, A., Aouzal, R., Ma, C., Long, D.-L. and Prunet, J. (2014) Highly efficient synthesis of the tricyclic core of Taxol by cascade metathesis. Organic Letters, 16(12), pp. 3300-3303. (doi:10.1021/ol501304j)

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Publisher's URL: http://dx.doi.org/10.1021/ol501304j

Abstract

An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning of the dienyne precursor is performed.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Prunet, Dr Joelle and Long, Dr De Liang and Letort, Mr Aurelien
Authors: Letort, A., Aouzal, R., Ma, C., Long, D.-L., and Prunet, J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Organic Letters
Journal Abbr.:Org. Lett.
Publisher:American Chemical Society
ISSN:1523-7060
ISSN (Online):1523-7052
Copyright Holders:Copyright © 2014 2014 American Chemical Society
First Published:First published in Organic Letters 16(12):330-3303
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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