Parasite infection is associated with Kaposi's sarcoma associated herpesvirus (KSHV) in Ugandan women

Wakeham, K., Webb, E. L., Sebina, I., Muhangi, L., Miley, W., Johnson, W. T., Ndibazza, J., Elliott, A. M., Whitby, D. and Newton, R. (2011) Parasite infection is associated with Kaposi's sarcoma associated herpesvirus (KSHV) in Ugandan women. Infectious Agents and Cancer, 6(1), p. 15. (doi:10.1186/1750-9378-6-15)

[img]
Preview
Text
94776.pdf - Published Version
Available under License Creative Commons Attribution.

353kB

Publisher's URL: http://dx.doi.org/10.1186/1750-9378-6-15

Abstract

Background: Immune modulation by parasites may influence susceptibility to bacteria and viruses. We examined the association between current parasite infections, HIV and syphilis (measured in blood or stool samples using standard methods) and antibodies against Kaposi's sarcoma herpesvirus (KSHV), measured by ELISA, in 1915 stored plasma samples from pregnant women in Entebbe, Uganda.

Results: Seroprevalence of KSHV was higher in women with malaria parasitaemia (73% vs 60% p = 0.01), hookworm (67% vs 56% p = 0.001) and Mansonella perstans (69% vs 59% p = 0.05); seroprevalence increased with increasing intensity of hookworm infection (p < 0.001[trend]). No associations were found for HIV, five other parasites or active syphilis. These effects were not explained by socioeconomic status or education.

Conclusions: Specific parasite infections are associated with presence of antibodies against KSHV, perhaps mediated via their effect on immune function.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wakeham, Dr Katie
Authors: Wakeham, K., Webb, E. L., Sebina, I., Muhangi, L., Miley, W., Johnson, W. T., Ndibazza, J., Elliott, A. M., Whitby, D., and Newton, R.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Infectious Agents and Cancer
Publisher:BioMed Central
ISSN:1750-9378
ISSN (Online):1750-9378
Copyright Holders:Copyright © 2011 The Authors
First Published:First published in Infectious Agents and Cancer 6(1):15
Publisher Policy:Reproduced under a Creative Commons License
Related URLs:

University Staff: Request a correction | Enlighten Editors: Update this record