Risk factors for seropositivity to Kaposi sarcoma–associated herpesvirus among children in Uganda

Wakeham, K. et al. (2013) Risk factors for seropositivity to Kaposi sarcoma–associated herpesvirus among children in Uganda. JAIDS: Journal of Acquired Immune Deficiency Syndromes, 63(2), pp. 228-233. (doi:10.1097/QAI.0b013e31828a7056)

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Publisher's URL: http://dx.doi.org/10.1097/QAI.0b013e31828a7056

Abstract

Background: Determinants of Kaposi sarcoma–associated herpesvirus (KSHV) seropositivity among children living in sub-Saharan African populations where infection is endemic are not well understood. Local environmental factors, including other infectious agents, may be key.

Methods: Within the context of a well-characterized birth cohort, we examined associations between various factors and antibodies against KSHV, measured in stored plasma samples from 1823 mother–child pairs in Entebbe, Uganda.

Results: Seroprevalence increased with increasing age of the child (P = 0.0003) and was higher among those with KSHV seropositive mothers than in those without (12% vs 9%; odds ratio: 1.4, 95% confidence interval: 1.1 to 2.0). It was also higher among children with HIV infection (29% vs 10%; odds ratio: 3.1, 95% confidence interval: 1.2 to 8.3) or malaria parasitemia (30% vs 10%; odds ratio: 4.1, 95% confidence interval: 2.4 to 7.0) than in children without. These associations were not explained by socioeconomic status.

Conclusions: The finding that KSHV serostatus is associated with malaria parasitemia in children is novel. In a country endemic for KSHV, malaria may be a cofactor for KSHV infection or reactivation among children.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Wakeham, Dr Katie
Authors: Wakeham, K., Webb, E. L., Sebina, I., Nalwoga, A., Muhangi, L., Miley, W., Johnston, W. T., Ndibazza, J., Whitby, D., Newton, R., and Elliott, A. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:JAIDS: Journal of Acquired Immune Deficiency Syndromes
Publisher:Lippincott, Williams & Wilkins
ISSN:1525-4135
ISSN (Online):1944-7884
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