Effective biological dose from occupational exposure during nanoparticle synthesis

Demou, E. , Tran, L. and Housiadas, C. (2009) Effective biological dose from occupational exposure during nanoparticle synthesis. Journal of Physics: Conference Series, 151(1), 012016. (doi: 10.1088/1742-6596/151/1/012016)

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Publisher's URL: http://dx.doi.org/10.1088/1742-6596/151/1/012016


Nanomaterial and nanotechnology safety require the characterization of occupational exposure levels for completing a risk assessment. However, equally important is the estimation of the effective internal dose via lung deposition, transport and clearance mechanisms. An integrated source-to-biological dose assessment study is presented using real monitoring data collected during nanoparticle synthesis. Experimental monitoring data of airborne exposure levels during nanoparticle synthesis of CaSO4 and BiPO4 nanoparticles in a research laboratory is coupled with a human lung transport and deposition model, which solves in an Eulerian framework the general dynamic equation for polydisperse aerosols using particle specific physical-chemical properties. Subsequently, the lung deposition model is coupled with a mathematical particle clearance model providing the effective biological dose as well as the time course of the biological dose build-up after exposure. The results for the example of BiPO4 demonstrate that even short exposures throughout the day can lead to particle doses of 1.10centerdotE+08#/(kg-bwcenterdot8h-shift), with the majority accumulating in the pulmonary region. Clearance of particles is slow and is not completed within a working shift following a 1 hour exposure. It mostly occurs via macrophage activity in the alveolar region, with small amounts transported to the interstitium and less to the lymph nodes.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Demou, Dr Evangelia
Authors: Demou, E., Tran, L., and Housiadas, C.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > MRC/CSO SPHSU
College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
Journal Name:Journal of Physics: Conference Series
Publisher:IOP Publishing
ISSN (Online):1742-6596

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