Concise review: cancer cells escape from oncogene addiction: understanding the mechanisms behind treatment failure for more effective targeting

Pellicano, F., Mukherjee, L. and Holyoake, T. L. (2014) Concise review: cancer cells escape from oncogene addiction: understanding the mechanisms behind treatment failure for more effective targeting. Stem Cells, 32(6), pp. 1373-1379. (doi: 10.1002/stem.1678) (PMID:24520002)

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Abstract

Oncogene addiction describes the dependence of some cancers on one or a few genes for their survival. Inhibition of the corresponding oncoproteins can lead to dramatic responses. However, in some cases, such as chronic myeloid leukemia (CML), a disease characterized by the presence of the abnormal fusion tyrosine kinase BCR-ABL, cancer stem cells may never acquire addiction to the oncogene that drives disease development. The suggested mechanism(s) for treatment failure include a quiescent stem cell population capable of reinstating disease, high levels of oncoprotein expression, or acquired mutations in the oncogene. In this review, we discuss the evidence for oncogene addiction in several solid tumors and their potential escape mechanism(s) with a particular focus on CML stem cells.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Holyoake, Professor Tessa and Pellicano, Dr Francesca and Mukherjee, Dr Leena
Authors: Pellicano, F., Mukherjee, L., and Holyoake, T. L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Stem Cells
Publisher:AlphaMed Press
ISSN:1066-5099
ISSN (Online):1549-4918

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
630761Investigation of the role of rho kinase in the survival of chronic myeloid leukaemia cellsLeena MukherjeeWellcome Trust (WELLCOME)101703/Z/13/ZRI CANCER SCIENCES
498551Key survival pathways in chronic myeloid leukaemic (CML) stem cells and novel approaches to their eradicationTessa HolyoakeCancer Research UK (CAN-RES-UK)11008RI CANCER SCIENCES
597331An investigation of hsa-mir183 and E2F1 role in CML LSCFrancesca PellicanoELIMINATION OF LEUKAEMIA FUND (ELF-FUND)ELF/6/29/1ICS - PAUL O'GORMAN LEUKAEMIA RESEARCH C