Pellicano, F., Mukherjee, L. and Holyoake, T. L. (2014) Concise review: cancer cells escape from oncogene addiction: understanding the mechanisms behind treatment failure for more effective targeting. Stem Cells, 32(6), pp. 1373-1379. (doi: 10.1002/stem.1678) (PMID:24520002)
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Abstract
Oncogene addiction describes the dependence of some cancers on one or a few genes for their survival. Inhibition of the corresponding oncoproteins can lead to dramatic responses. However, in some cases, such as chronic myeloid leukemia (CML), a disease characterized by the presence of the abnormal fusion tyrosine kinase BCR-ABL, cancer stem cells may never acquire addiction to the oncogene that drives disease development. The suggested mechanism(s) for treatment failure include a quiescent stem cell population capable of reinstating disease, high levels of oncoprotein expression, or acquired mutations in the oncogene. In this review, we discuss the evidence for oncogene addiction in several solid tumors and their potential escape mechanism(s) with a particular focus on CML stem cells.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Holyoake, Professor Tessa and Pellicano, Dr Francesca and Mukherjee, Dr Leena |
Authors: | Pellicano, F., Mukherjee, L., and Holyoake, T. L. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Stem Cells |
Publisher: | AlphaMed Press |
ISSN: | 1066-5099 |
ISSN (Online): | 1549-4918 |
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