Optimising outcome assessment to improve quality and efficiency of stroke trials

McArthur, K., Fan, Y., Pei, Z. and Quinn, T. (2014) Optimising outcome assessment to improve quality and efficiency of stroke trials. Expert Review of Pharmacoeconomics and Outcomes Research, 14(1), pp. 101-111. (doi: 10.1586/14737167.2014.870479)

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Abstract

Substantial progress has been made in treatment of stroke and much of this has been driven by large scale, multi-centre, randomised controlled trials. Although stroke is a frequent cause of mortality, stroke-related disability and functional decline is of equal or greater concern to patients and carers. Thus, to prove efficacy of an intervention for stroke, we need robust methods of describing recovery. Various functional assessment scales are available, the tool recommended as trial end point by many specialist societies and regulatory authorities is the modified Rankin Scale (mRS). We will use the mRS as exemplar to discuss contemporary research around functional assessment for stroke trials, including recent work around structured assessments, assessor training and end point adjudication panels. We will present an overview and critique of these studies and give examples where strategies to improve mRS assessment are impacting on the quality of stroke clinical trials.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McArthur, Dr Kate and Quinn, Professor Terry
Authors: McArthur, K., Fan, Y., Pei, Z., and Quinn, T.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Expert Review of Pharmacoeconomics and Outcomes Research
Publisher:Expert Reviews Ltd.
ISSN:1473-7167
ISSN (Online):1744-8379

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