Prada Jiménez de Cisneros, J., Matthews, L. , Mair, C. , Stefan, T. and Stear, M. J. (2014) The transfer of IgA from mucus to plasma and the implications for diagnosis and control of nematode infections. Parasitology, 141(7), pp. 875-879. (doi: 10.1017/S0031182013002321)
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Abstract
Immunoglobulin A (IgA) activity has been associated with reduced growth and fecundity of Teladorsagia circumcincta. IgA is active at the site of infection in the abomasal mucus. However, while IgA activity in abomasal mucus is not easily measured in live animals without invasive methods, IgA activity can be readily detected in the plasma, making it a potentially valuable tool in diagnosis and control. We used a Bayesian statistical analysis to quantify the relationship between mucosal and plasma IgA in sheep deliberately infected with T. circumcincta. The transfer of IgA depends on mucosal IgA activity as well as its interaction with worm number and size; together these account for over 80% of the variation in plasma IgA activity. By quantifying the impact of mucosal IgA and worm number and size on plasma IgA, we provide a tool that can allow more meaningful interpretation of plasma IgA measurements and aid the development of efficient control programmes.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Mair, Dr Colette and Stefan, Mr Thorsten and Stear, Professor Mike and Matthews, Professor Louise and Prada Jimenez de Cisneros, Dr Joaquin |
Authors: | Prada Jiménez de Cisneros, J., Matthews, L., Mair, C., Stefan, T., and Stear, M. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity College of Medical Veterinary and Life Sciences > School of Biodiversity, One Health & Veterinary Medicine |
Journal Name: | Parasitology |
Publisher: | Cambridge University Press |
ISSN: | 0031-1820 |
ISSN (Online): | 1469-8161 |
Copyright Holders: | Copyright © 2014 Cambridge University Press |
First Published: | First published in Parasitology 141(7):875-879 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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