Gao, H. , Allan, A., McComb, C., Luo, X. and Berry, C. (2014) Left ventricular strain and its pattern estimated from cine CMR and validation with DENSE. Physics in Medicine and Biology, 59(13), pp. 3637-3656. (doi: 10.1088/0031-9155/59/13/3637)
Full text not currently available from Enlighten.
Publisher's URL: http://dx.doi.org/10.1088/0031-9155/59/13/3637
Abstract
Measurement of local strain provides insight into the biomechanical significance of viable myocardium. We attempted to estimate myocardial strain from cine cardiovascular magnetic resonance (CMR) images by using a b-spline deformable image registration method. 3 healthy volunteers and 41 patients with either recent or chronic myocardial infarction (MI) were studied at 1.5 Tesla with both cine and DENSE CMR. Regional circumferential and radial left ventricular strains were estimated from cine and DENSE acquisitions. In all healthy volunteers, there was no difference for peak circumferential strain (-0.18±0.04 vs. -0.18±0.03, p=0.76) between cine and DENSE CMR, however peak radial strain was overestimated from cine (0.84±0.37 vs. 0.49±0.2, p<0.01). In the patient study, the peak strain patterns predicted by cine were similar to the patterns from DENSE, including the strain evolution related to recovery time and strain patterns related to MI scar extent. Furthermore, cine-derived strain disclosed different strain patterns in MI and non-MI regions, and regions with transmural and non-transmural MI as DENSE. Although there were large variations with radial strain measurements from cine CMR images, useful circumferential strain information can be obtained from routine clinical CMR imaging. Cine strain analysis has potential to improve the diagnostic yield from routine CMR imaging in clinical practice.
| Item Type: | Articles |
|---|---|
| Keywords: | myocardial strain, deformable image registration, DENSE, myocardial infarction |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Luo, Professor Xiaoyu and Gao, Dr Hao and Berry, Professor Colin |
| Authors: | Gao, H., Allan, A., McComb, C., Luo, X., and Berry, C. |
| Subjects: | Q Science > Q Science (General) |
| College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health College of Science and Engineering > School of Mathematics and Statistics > Mathematics |
| Journal Name: | Physics in Medicine and Biology |
| Publisher: | IOP Publishing |
| ISSN: | 0031-9155 |
| ISSN (Online): | 1361-6560 |
| Copyright Holders: | Copyright © 2014 Institute of Physics and Engineering in Medicine |
| First Published: | First published in Physics in Medicine and Biology 59(13):3637-3656 |
| Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
University Staff: Request a correction | Enlighten Editors: Update this record
Funder and Project Information
Funder and Project Information