Left ventricular strain and its pattern estimated from cine CMR and validation with DENSE

Gao, H. , Allan, A., McComb, C., Luo, X. and Berry, C. (2014) Left ventricular strain and its pattern estimated from cine CMR and validation with DENSE. Physics in Medicine and Biology, 59(13), pp. 3637-3656. (doi:10.1088/0031-9155/59/13/3637)

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Publisher's URL: http://dx.doi.org/10.1088/0031-9155/59/13/3637

Abstract

Measurement of local strain provides insight into the biomechanical significance of viable myocardium. We attempted to estimate myocardial strain from cine cardiovascular magnetic resonance (CMR) images by using a b-spline deformable image registration method. 3 healthy volunteers and 41 patients with either recent or chronic myocardial infarction (MI) were studied at 1.5 Tesla with both cine and DENSE CMR. Regional circumferential and radial left ventricular strains were estimated from cine and DENSE acquisitions. In all healthy volunteers, there was no difference for peak circumferential strain (-0.18±0.04 vs. -0.18±0.03, p=0.76) between cine and DENSE CMR, however peak radial strain was overestimated from cine (0.84±0.37 vs. 0.49±0.2, p<0.01). In the patient study, the peak strain patterns predicted by cine were similar to the patterns from DENSE, including the strain evolution related to recovery time and strain patterns related to MI scar extent. Furthermore, cine-derived strain disclosed different strain patterns in MI and non-MI regions, and regions with transmural and non-transmural MI as DENSE. Although there were large variations with radial strain measurements from cine CMR images, useful circumferential strain information can be obtained from routine clinical CMR imaging. Cine strain analysis has potential to improve the diagnostic yield from routine CMR imaging in clinical practice.

Item Type:Articles
Keywords:myocardial strain, deformable image registration, DENSE, myocardial infarction
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Gao, Dr Hao and Luo, Professor Xiaoyu and Berry, Professor Colin
Authors: Gao, H., Allan, A., McComb, C., Luo, X., and Berry, C.
Subjects:Q Science > Q Science (General)
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Science and Engineering > School of Mathematics and Statistics > Mathematics
Journal Name:Physics in Medicine and Biology
Publisher:IOP Publishing
ISSN:0031-9155
ISSN (Online):1361-6560
Copyright Holders:Copyright © 2014 Institute of Physics and Engineering in Medicine
First Published:First published in Physics in Medicine and Biology 59(13):3637-3656
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
560111Finite element-immersed boundary method and its application to mitral valvesXiaoyu LuoEngineering & Physical Sciences Research Council (EPSRC)EP/I029990/1M&S - MATHEMATICS