Chamberlain, L. H. (2001) Inhibition of isoprenoid biosynthesis causes insulin resistance in 3T3-L1 adipocytes. FEBS Letters, 507(3), pp. 357-361. (doi: 10.1016/S0014-5793(01)03007-1)
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Publisher's URL: http://dx.doi.org/10.1016/S0014-5793(01)03007-1
Abstract
Lovastatin treatment caused down-regulation of the insulin-responsive glucose transporter 4 (Glut4) and up-regulation of Glut1 in 3T3-L1 adipocytes. These changes in protein expression were associated with a marked inhibition of insulin-stimulated glucose transport. Lovastatin had no effect on cell cholesterol levels, but its effects were reversed by mevalonate, demonstrating that inhibition of isoprenoid biosynthesis causes insulin resistance in 3T3-L1 adipocytes. These findings support the notion that whole body insulin resistance may arise as a result of perturbations in general biochemical pathways, rather than primary defects in insulin signalling.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Chamberlain, Dr Luke |
| Authors: | Chamberlain, L. H. |
| College/School: | College of Medical Veterinary and Life Sciences |
| Journal Name: | FEBS Letters |
| Publisher: | Elsevier BV |
| ISSN: | 0014-5793 |
| ISSN (Online): | 1873-3468 |
| Published Online: | 02 November 2001 |
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