The application of glycosphingolipid arrays to autoantibody detection in neuroimmunological disorders

Galban-Horcajo, F., Halstead, S. K., McGonigal, R. and Willison, H. J. (2014) The application of glycosphingolipid arrays to autoantibody detection in neuroimmunological disorders. Current Opinion in Chemical Biology, 18, pp. 78-86. (doi:10.1016/j.cbpa.2014.01.008)

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Publisher's URL: http://dx.doi.org/10.1016/j.cbpa.2014.01.008

Abstract

Humans with autoimmune peripheral neuropathies frequently harbour serum antibodies to single glycosphingolipids, especially gangliosides. Recently it has been appreciated that glycolipid and lipid complexes, formed from two or more individual species, can interact to create molecular shapes capable of being recognised by these autoantibodies whilst not binding to the single individuals. As a result of this, novel autoantibody targets have been identified. This newly termed ‘combinatorial glycomic’ approach has provided the impetus to redesigning the assay methodologies traditionally used in the neuropathy-associated autoantibody field. Combinatorial glycoarrays can be readily constructed in house using lipids of interest. Herein we especially highlight the role of the neutral lipids cholesterol and galactocerebroside in modifying glycosphingolipid orientation that subsequently favours or inhibits autoantibody binding.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Halstead, Dr Susan and Willison, Professor Hugh and McGonigal, Dr Rhona and Galban, Mr Francesc
Authors: Galban-Horcajo, F., Halstead, S. K., McGonigal, R., and Willison, H. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Current Opinion in Chemical Biology
Publisher:Elsevier Ltd., Current Opinion Journals
ISSN:1367-5931
ISSN (Online):1879-0402

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